Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas
نویسندگان
چکیده
منابع مشابه
Influence of the microwave technology on solid dispersions of mefenamic acid and flufenamic acid
The present studies were undertaken to develop solvent-free solid dispersions (SDs) for poorly soluble anti-inflammatory drugs mefenamic acid (MA) and flufenamic acid (FFA) in order to enhance their in vitro dissolution rate and in vivo anti-inflammatory effects. The SDs of MA and FFA were prepared using microwaves irradiation (MW) technique. Different carriers such as Pluronic F127® (PL), Eudr...
متن کاملActivation of Slo2.1 channels by niflumic acid
Slo2.1 channels conduct an outwardly rectifying K(+) current when activated by high [Na(+)](i). Here, we show that gating of these channels can also be activated by fenamates such as niflumic acid (NFA), even in the absence of intracellular Na(+). In Xenopus oocytes injected with <10 ng cRNA, heterologously expressed human Slo2.1 current was negligible, but rapidly activated by extracellular ap...
متن کاملDifferential Modulation of c~3p2 and a3p4 Neuronal Nicotinic Receptors Expressed in Xenopus Oocytes by Flufenamic Acid and Niflumic Acid
Effects of flufenamic acid (FFA) and niflumic acid (NFA), which are often used to block Ca2+-activated Clcurrent, have been investigated in voltage-clamped Xenopus oocytes expressing 01392 and a364 nicotinic ACh receptors (nAChRs). NFA and FFA inhibit a362 nAChR-mediated inward currents and potentiate ~364 nAChR-mediated inward currents in normal, Cl--free and Ca*+-free solutions to a similar e...
متن کاملMefenamic acid enteropathy.
The clinical, radiological, and histological features of two patients with severe intestinal damage induced by mefenamic acid and mimicking coeliac disease are described. Symptoms rapidly reverted on withdrawal of the drug, and in one case, did not relapse during treatment with other non-steroidal anti-inflammatory drugs.
متن کاملVoltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid
Niflumic acid (NFA) is a member of the fenamate class of nonsteroidal anti-inflammatory drugs. This compound and its derivatives are used worldwide clinically for the relief of chronic and acute pain. NFA is also a commonly used blocker of voltage-gated chloride channels. Here we present evidence that NFA is an efficient blocker of chloride-permeable glycine receptors (GlyRs) with subunit heter...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1990
ISSN: 0014-5793
DOI: 10.1016/0014-5793(90)80977-q